|
rs121913483
|
|
|
0.710 |
GeneticVariation |
BEFREE |
PIK3CA showed a uniquely high rate of mutations within the helicase domain, and FGFR3 contained a predominance of hotspot S249C alterations that were not found in HPV- HNSCC.
|
30933315 |
2019 |
|
rs1695
|
|
|
0.050 |
GeneticVariation |
BEFREE |
GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms in outcomes of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation.
|
31249357 |
2019 |
|
rs17568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of OX40 gene polymorphisms (rs17568G/A and rs229811A/C) with head and neck squamous cell carcinoma.
|
30923998 |
2019 |
|
rs229811
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of OX40 gene polymorphisms (rs17568G/A and rs229811A/C) with head and neck squamous cell carcinoma.
|
30923998 |
2019 |
|
rs121912656
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhances the invasive cell growth of p53-deficient head and neck squamous cell carcinoma (HNSCC) UM-SCC-1 cells both in in vitro three-dimensional culture and in an in vivo orthotopic nude mouse model of HNSCC through a novel transcription-independent mechanism.
|
29269868 |
2018 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We evaluated the correlation of the x-ray repair cross complementing gene 1 (XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients treated with concurrent chemoradiation therapy (CCRT).
|
29893275 |
2018 |
|
rs1052133
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our meta-analysis results indicated that <i>hOGG1</i> Ser326Cys polymorphism may be associated with increased risk of HNSCC, especially in Caucasians, alcohol drinkers and the patients with laryngeal squamous cell carcinoma.
|
29560133 |
2018 |
|
rs11016879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MGMT rs11016879 AG genotype and A allele were associated with increased HNSCC risk.
|
29370316 |
2018 |
|
rs12917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that the MGMT rs12917 TT genotype increases the risk of HNSCC.
|
29370316 |
2018 |
|
rs2273535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Aurora-Kinase A Phe31-Ile polymorphism as possible predictor of response to treatment in head and neck squamous cell carcinoma.
|
29560108 |
2018 |
|
rs26537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, we identified that rs26537 of ATG12 (additive model: adjusted odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.03-1.37, P = 0.017) and rs4663402 in ATG16L1 (additive model: adjusted OR = 1.39, 95%CI = 1.08-1.80, P = 0.010) were significantly associated with the increased risk of HNSCC.
|
29637616 |
2018 |
|
rs4663402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, we identified that rs26537 of ATG12 (additive model: adjusted odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.03-1.37, P = 0.017) and rs4663402 in ATG16L1 (additive model: adjusted OR = 1.39, 95%CI = 1.08-1.80, P = 0.010) were significantly associated with the increased risk of HNSCC.
|
29637616 |
2018 |
|
rs4759314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HOTAIR rs4759314 may influence HNSCC susceptibility and serve as a diagnostic biomarker.
|
29461598 |
2018 |
|
rs7958904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there were no significant associations of rs874945 and rs7958904 with HNSCC risk.
|
29461598 |
2018 |
|
rs874945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there were no significant associations of rs874945 and rs7958904 with HNSCC risk.
|
29461598 |
2018 |
|
rs9350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This prospective study aimed to investigate whether <i>MLH1</i> c.-93G>A (rs1800734), <i>MSH2</i> c.211+9C>G (rs2303426), <i>MSH3</i> c.3133G>A (rs26279), <i>EXO1</i> c.1765G>A (rs1047840), and <i>EXO1</i> c.2270C>T (rs9350) single nucleotide polymorphisms (SNPs) of the mismatch repair (MMR) pathway change side effects and response rate of 90 HNSCC patients treated with CDDP and RT.
|
30038702 |
2018 |
|
rs2910164
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In summary, variant alleles of miR-146a rs2910164 alleles may have an association with the increased risk of SCCHN in Chinese patients, and these associations differed based on tumor site.
|
29049342 |
2017 |
|
rs13181
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs1034220998
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs11615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs121434569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher frequency of EGFR-TK domain mutations together with the presence of the T790M mutation suggests that identification of these mutations might streamline the therapy and provide a better prognosis in HNSCC cases.
|
28352186 |
2017 |
|
rs1256743514
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The mutational analysis in the eight HNSCC cell lines revealed an <i>EGFR</i> mutation (p.H773Y) and gene amplification in the HN13 cells.
|
28881811 |
2017 |
|
rs17084687
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, interaction analyses revealed a significant multiplicative interaction between rs17084687 and drinking on HNSCC risk (P = 0.012).
|
27186940 |
2017 |
|
rs1799793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
XPD c.934G>A polymorphism of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation.
|
26918827 |
2017 |
|
rs1799801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |